synbio – Page 5 – My WordPress Site

Overview of model architecture, training procedure, datasets, and evaluations for Evo 2.

AI - Data - Apps - Cybernetics, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Citizen Science / Open Science, Commercial & Private Sector, Genomics, Proteomics, Bioinformatics, Nanotechnology & SynBio

Genome Modeling And Design Across All Domains Of Life With Evo 2

by Keith CowingFebruary 21, 2025March 7, 2026

A codon, a sequence of three nucleotides in DNA and RNA that codes for a specific amino acid, acts like an “instruction manual” for protein synthesis, telling the cell which of the 20 natural amino acids to add to a growing protein chain — or, in the case of the three “stop” codons (known as TAG, TGA, and TAA), signaling the termination of protein synthesis. Yale scientists recoded a cell to have a single, non-degenerative TAA codon. The newly “free” TGA and TAG codons have been reassigned to encode nonstandard amino acids into synthetic proteins that possess new chemistries with innumerable applications. Credit Yale University / Michael S. Helfenbein

Biochemistry & Organic Chemistry, Biophysics, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Nanotechnology & SynBio, Origin & Evolution of Life

Recoding A Genome For Programmable Synthetic Proteins

by Keith CowingFebruary 11, 2025

Circular genomic map of Med1 obtained from PHASTEST. -- Scientific Reports Agência FAPESP

Arctic / Antarctic / Alpine, Away Teams & Field Reports, Biochemistry & Organic Chemistry, Commercial & Private Sector, Extremeophiles and Extreme Environments, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Nanotechnology & SynBio, Polar / Alpine Expeditions, Sample Return

Extremophile Spinoffs: Bioactive Compounds Identified In Bacteria From The Andes

by Keith CowingJanuary 21, 2025January 21, 2025

Taq polymerase. © Emphase / EPFL

Astropharmacy / Biotechnology, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Extremeophiles and Extreme Environments, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Nanotechnology & SynBio, Origin & Evolution of Life

The Extremophile Protein That Revolutionized DNA Sequencing

by Keith CowingJanuary 16, 2025January 16, 2025

Library cleaning and accuracy determination workflow. In this study, (A) two GCMS spectral libraries (NIST17 and MoNA) were filtered to include only experimental spectra from monosubstituted α-amino acids. A third library (IOCB) was composed of experimental GCMS spectra from seventeen amino acids, also not found in the NIST dataset. (B) The accuracy of predicted GCMS spectra is measured through three metrics: root mean square error, spectral contrast angle, and weighted cosine similarity. -- chemrxiv.org

Astrochemistry, Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Imaging & Spectroscopy, Nanotechnology & SynBio

Mapping the Edges of Mass Spectral Prediction: Evaluation of Machine Learning EIMS Prediction for Xeno Amino Acids

by Keith CowingJanuary 15, 2025January 15, 2025

Graphical Abstract -- Life

Biophysics, Biosignatures & Paleobiology, Commercial & Private Sector, Extremeophiles and Extreme Environments, Habitable Zones, Microbiology & Virology, Nanotechnology & SynBio, Origin & Evolution of Life

Extremophiles and Extremophilic Behaviour – New Insights and Perspectives

by Keith CowingJanuary 13, 2025January 12, 2025

Obtaining the gradient of what's known as the loss function is an essential step to establish the backpropagation algorithm developed by University of Michigan researchers to train a material. The researchers showed the gradient could be found experimentally using a 3D-printed model of a mechanical neural network. Credit S. Li and X. Mao, Nat. Commun. 2024, DOI: 10.1038/s41467-024-54849-z)

AI - Data - Apps - Cybernetics, Intelligence & Language, Nanotechnology & SynBio

Non-Living Intelligence: Cracking The Code For Materials That Can Learn

by Keith CowingDecember 23, 2024December 23, 2024

Xeno nucleic acids (XNAs) -- JSC via PubMed

Biochemistry & Organic Chemistry, Biophysics, Biosignatures & Paleobiology, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Nanotechnology & SynBio

Expanding the Horizon of the Xeno Nucleic Acid Space

by Keith CowingDecember 16, 2024December 16, 2024

Researchers have created two types of synthetic protocells that can communicate with each other. (Image created with DALL-E) -- University of Basel

Astropharmacy / Biotechnology, Biochemistry & Organic Chemistry, Biophysics, Commercial & Private Sector, Genomics, Proteomics, Bioinformatics, Microbiology & Virology, Nanotechnology & SynBio, Origin & Evolution of Life

Synthetic Cells Emulate Natural Cellular Communication

by Keith CowingNovember 13, 2024November 13, 2024

Bioinspired hydrogels that convert water into hydrogen fuel using sunlight, effectively mimicking natural processes to create a sustainable energy solution. Credit Kosuke Okeyoshi from JAIST.

Biochemistry & Organic Chemistry, Genomics, Proteomics, Bioinformatics, Life Support Systems, Nanotechnology & SynBio, Plant Biology, Space Life Science

Hydrogels Harness Sunlight: A Step Closer To Artificial Photosynthesis

by Keith CowingNovember 7, 2024November 7, 2024